Redox Regulation of Mitochondrial ATP Synthase

Redox regulation of mitochondrial ATP synthase: implications for cardiac resynchronization therapy.

RATIONALE Cardiac resynchronization therapy (CRT) is an effective clinical treatment for heart failure patients with conduction delay, impaired contraction, and energetics. Our recent studies have revealed that mitochondrial posttranslational modifications (PTM) may contribute to its benefits, motivating the present study of the oxidative regulation of mitochondrial ATP synthase. OBJECTIVES W...

Molecular Medicine Redox Regulation of Mitochondrial ATP Synthase Implications for Cardiac Resynchronization Therapy

Regulation of the mitochondrial ATP synthase in rat heart.

Introduction lJnder normal physiological conditions, the heart is fully aerobic with over 90% of its ATP made in the mitochondria by oxidative phosphorylation. It is vital, therefore, that mitochondrial ATP synthesis is closely balanced with ATP use during contraction, so that a steady-state level of ATP (typically about 5 pmol/g of wet weight) can be maintained. When ATP is used more quickly (...

Regulation of mitochondrial ATP synthase activity in human myocardium.

1. In previous studies regulation of the F1F0-ATPase of mitochondrial complex V (ATP synthase) has been demonstrated in rat cardiomyocytes, canine mycocardium and skeletal muscle from children. The aim of the present study was to examine regulation of ATP synthase in human myocardium in response to different metabolic states. 2. Biopsy material was obtained from 10 children undergoing cardiac s...

Regulation of mitochondrial ATP synthase in cardiac pathophysiology.

Mitochondrial function is paramount to energy homeostasis, metabolism, signaling, and apoptosis in cells. Mitochondrial complex V (ATP synthase), a molecular motor, is the ultimate ATP generator and a key determinant of mitochondrial function. ATP synthase catalyzes the final coupling step of oxidative phosphorylation to supply energy in the form of ATP. Alterations at this step will crucially ...